Bisakah Obat Jantung Membantu Mengobati Kanker?

Ketika sel-sel dalam tubuh manusia menua secara tidak benar, ini terkadang membuat kanker lebih mudah berkembang atau menyebar. Untuk alasan ini, para ilmuwan mencari obat baru yang dapat bertindak pada proses yang berhubungan dengan penuaan sel. Tetapi bisakah obat yang ada berguna? Penuaan sel – yang oleh para ilmuwan disebut penuaan – adalah proses alami yang memungkinkan tubuh menyaring sel-sel tua dan rusak yang tidak lagi memenuhi tujuannya.
Namun, penuaan terkadang tidak berfungsi, dan beberapa peneliti percaya bahwa ini dapat berkontribusi pada pertumbuhan dan penyebaran tumor kanker. Dengan demikian, para spesialis telah bekerja keras untuk menemukan obat-obatan baru, yang mereka sebut senolitik, yang dapat membunuh sel-sel tua yang dapat mengancam kesehatan.
Penelitian sebelumnya. Sumber terpercaya dalam model hewan menunjukkan bahwa senolitik dapat memiliki sejumlah manfaat, termasuk menjaga individu tetap sehat untuk jangka waktu yang lebih lama dan memperpanjang umur. Dan beberapa senolitik, seperti navitoclaxTrusted Source, telah menunjukkan beberapa efektivitas dalam mengobati kanker darah, termasuk leukemia dan limfoma. Namun navitoclax juga dapat memiliki efek samping yang serius, termasuk trombositopenia, atau kadar trombosit rendah yang abnormal dalam darah.
Namun, baru-baru ini, para peneliti dari Institut Ilmu Kedokteran MRC London di Inggris mungkin telah mengidentifikasi senolitik alternatif – dalam bentuk obat jantung yang ada yang dikenal sebagai ouabain.
‘Obat-obatan ini bisa digunakan ulang’
Dalam makalah penelitian yang muncul dalam jurnal Nature Metabolism, para peneliti menjelaskan bahwa mereka bereksperimen dengan berbagai obat yang ada, mengujinya pada sel sehat dan tua untuk melihat bagaimana mereka akan bertindak.
Dengan melakukan itu, mereka mendekati ouabain, senyawa yang membentuk bagian dari kelas obat yang sama dengan digoxin dan digitoxin, yaitu glikosida jantung. Senyawa tersebut dapat mengobati kondisi jantung, termasuk aritmia jantung dan fibrilasi atrium, yang keduanya memiliki karakteristik detak jantung tidak teratur atau abnormal.
Tim peneliti menemukan bahwa ouabain dapat secara selektif membunuh berbagai jenis sel penuaan, termasuk yang telah menjadi tua karena kanker, atau karena paparan radioterapi atau kemoterapi, termasuk perawatan dengan obat-obatan seperti etoposide dan doxorubicin. Hal ini menjadikan ouabain kandidat potensial untuk digunakan sebagai senolitik spektrum luas: obat yang menargetkan beragam sel penuaan.
Para peneliti mencapai kesimpulan ini dengan menguji obat in vivo, pada tikus yang menua, dan “pada lesi prakanker di hati dan pada radioterapi,” seperti penulis senior Prof. Jesús Gil menjelaskan. Prof. Gil dan rekannya juga menunjukkan bahwa fakta bahwa sudah tersedia membuat penelitian lebih lanjut menggunakan obat ini lebih mudah.
“Obat-obatan ini sudah digunakan di klinik, sehingga dapat digunakan kembali untuk mengobati daftar penyakit yang panjang, termasuk kanker. Ini adalah sesuatu yang kami ingin jelajahi dengan kolaborator klinis kami.” Prof. Jesús Gil
“Selain itu,” tambah penulis senior, “banyak pasien sedang dirawat dengan digoxin, dan seorang ahli epidemiologi dapat melihat secara retrospektif dan mengajukan pertanyaan apakah pasien yang diobati dengan digoxin memiliki kinerja yang lebih baik daripada mereka yang tidak.”
Dengan demikian, penelitian di masa depan dapat membandingkan hasil kesehatan untuk orang yang telah menerima pengobatan dengan glikosida jantung dibandingkan dengan mereka yang belum, sehingga memudahkan untuk mengkonfirmasi apakah kelas obat ini memiliki potensi yang sebenarnya sebagai senolitik.

sumber : medical news today

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